Cancer Cell Migration under Physical Stimulations
Chau-Hwang Lee1,2*
1Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan
2Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan
* presenting author:Chau-Hwang Lee, email:clee@gate.sinica.edu.tw
The microenvironment in a tumor is very different from those in normal tissues. Previous studies were focused on the effects of chemical stimulations such as cytokines and growth factors related to cancer cell activities. Recently scientists pay more and more attentions in the physical stimulations related to tumor growth and cancer metastasis. In this presentation I will report some of our works about the effects of physical stimulations on cancer cell migration, including electric fields, optical micropatterns, cyclic tensile strain, and substrate rigidity. These physical stimulations work on the cancer cells directly or on the interactions between cancer cells and nearby stromal cells. Because the physical stimulations can be controlled in a precise way, we also demonstrated the modulation of chemotaxis using electrical signals. These studies shed light on mediating cancer metastasis in physical ways.


Keywords: Cancer metastasis, Physical stimulations, Cell migration