Quantum sequencing: reading the genetic code with quantum mechanics
Massimiliano Di Ventra1*
1Physics, UC San Diego, La Jolla, CA, United States of America
* presenting author:Massimiliano Di Ventra, email:diventra@physics.ucsd.edu
Personalized or precision medicine refers to the ability of tailoring drugs to the specific genome and transcriptome of each individual [1]. It is however not yet feasible due the high costs and slow speed of present DNA sequencing methods. I will discuss a sequencing protocol we have suggested that requires the measurement of the distributions of transverse tunneling currents during the translocation of single-stranded DNA into nanochannels [2-5]. I will show that such a quantum sequencing approach can reach unprecedented speeds, without requiring any chemical preparation, amplification or labeling thus truly opening up the possibility of personalized medicine. I will also discuss recent experiments that support these theoretical predictions [6], and now form the core technology of the commercial sequencers being produced at Quantum Biosystems Inc. (http://www.quantumbiosystems.com/).

[1.] M. Zwolak, M. Di Ventra, Rev. Mod. Phys. 2008, 80, 141.
[2.] M. Zwolak and M. Di Ventra, Nano Lett. 5, 421 (2005).
[3.] J. Lagerqvist, M. Zwolak, and M. Di Ventra, Nano Lett., 2006 6, 779.
[4.] J. Lagerqvist, M. Zwolak, and M. Di Ventra, Biophys. J. 2007, 93, 2384.
[5.] M. Krems, M. Zwolak, Y.V. Pershin, and M. Di Ventra, Biophys. J. 2009, 97, 1990.
[6.] T. Ohshiro, K. Matsubara, M. Tsutsui, M. Furuhashi, M. Taniguchi and T. Kawai, Nature: Scientific Reports, 2012, 2, 501.


Keywords: Quntum Transport, DNA